The skin secretions of a South American frog could be used to treat type 2 diabetes.
is the "paradoxical frog", so named because as it develops its size is reduced and the tadpole is 5 times larger than their parents.
Scientists say a compound isolated from the amphibian, the pseudin-2, may stimulate insulin release.
With a synthetic version of the compound, the scientists say, could produce new drugs for type 2 diabetes.
In recent years there have been many investigations on the biological activity molecules in the skin secretions of amphibians and reptiles.
"Some time ago a substance found in the saliva of a lizard, called exendin" he told BBC Science Dr. Adela Rovira, vice president of the English Society of Diabetes and author of "Everything for diabetes."
The exendin was discovered in the saliva of the Gila monster, a lizard species inhabiting the American Southwest and northern Mexico.
"With the exendin-adds the researcher, also developed a synthetic compound that acts by releasing insulin."
The study, presented at the annual conference of the British charity Diabetes UK, was conducted by researchers from Universities of Ulster and United Arab Emirates.
Scientists say a compound isolated from the amphibian, the pseudin-2, may stimulate insulin release.
With a synthetic version of the compound, the scientists say, could produce new drugs for type 2 diabetes.
In recent years there have been many investigations on the biological activity molecules in the skin secretions of amphibians and reptiles.
"Some time ago a substance found in the saliva of a lizard, called exendin" he told BBC Science Dr. Adela Rovira, vice president of the English Society of Diabetes and author of "Everything for diabetes."
The exendin was discovered in the saliva of the Gila monster, a lizard species inhabiting the American Southwest and northern Mexico.
"With the exendin-adds the researcher, also developed a synthetic compound that acts by releasing insulin."
The study, presented at the annual conference of the British charity Diabetes UK, was conducted by researchers from Universities of Ulster and United Arab Emirates.
Insulin Type 2 diabetes, often associated with obesity and overweight is caused when the body fails to produce enough insulin or when not properly assimilate the insulin it produces.
This causes the person can not properly regulate their blood glucose levels in the blood.
The researchers hope to test the compound in patients humanos.Los researchers found that pseudin-2, which protects the paradoxical frog from infection, could stimulate insulin secretion in pancreatic cells analyzed in the laboratory.
And most importantly, they say, is that no produced toxic effects on cells.
addition, the synthetic version of pseudin-2 was more effective to stimulate insulin release than the natural compound of the frog.
The pseudin-2 is a peptide, a block for the formation of proteins, which could serve to develop a new class of drugs for type 2 diabetes called incretin.
injected These are drugs that stimulate insulin secretion in patients with type 2 diabetes. Therapies
"Right now we already have drugs that stimulate insulin secretion through mechanisms incretin" explains Dr. Adela Rovira.
"One is the synthetic version of exendin-derived from the saliva of the Gila monster, which is already marketed in the United States."
long ago found a substance in the saliva of a lizard, called exendin, with which we developed a synthetic compound that acts by releasing insulin
Dr. Adela Rovira, English Society of Diabetes "And another is a homologue of a substance called GLP -1 to have the people and that is also in advanced stages of research, "he adds.
Experts believe that with the pseudin-2, which hope to test soon in human patients may also develop a drug of incretins. According to the Organization
World Health Organization, about 195 million people have diabetes worldwide, and most of them suffer from type 2 diabetes.
Type 2 diabetes is a disease that can be effectively controlled with medication administration.
And a good control of diabetes reduces the risk of complications such as blindness, heart disease, kidney problems and amputations.
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